While the first implementation of this project used RS-232 protocol for communication between the Picaxe and the Nano33BLE, this uses I2C. Using RS-232 required the Picaxe to furnish an interrupt signal before the message, I2C does not since the hardware I2C interface works in the background, and is buffered. A handler is called when an I2C signal is received, Nevertheless, the interrupt circuity is still present in the receiver as it is still required to process the RF transmissions,
The Nano33BLE is a 3.3V micro-controller, It has a low-dropout regulator to accept an input higher than 5V. It is primary expected to be powered from its USB jack but this project is not connected to a computer in normal service. A Vin pin accepts from 5 to 18V, but a 7805 regulator provides 5V because this is required by the Radiotronix Super-Regen 433 MHZ Receiver.
While the particular 7805 used has no special marking it has the non-specified behavior of shutting down for input voltages over 10V. The only power supply to use is labelled Medical Power Supply which furnishes 9.35V.